Researchers at the University of Minnesota have discovered that a natural compound, found in particular in certain fruits and vegetables, helps reduce the level of damaged or senescent cells in the body associated with aging. This work presented in EBioMedicine pursues one of the main ways to fight against aging, the elimination of aging cells.
Recent research has shown that it is possible to reduce the burden of damaged or senescent cells, thereby extending lifespan and improving health, even when treatment is initiated late in life. This new study conducted on mice shows that the treatment of elderly mice with this compound, Fisetin, present in many fruits and vegetables, induces significant positive effects on health and lifespan.
Cellular senescence leads to tissue breakdown: as people age, they accumulate damaged cells. When the cells reach a certain level of damage, they go through a process of cellular senescence, then releasing inflammatory factors which push the immune system to eliminate these damaged cells. A younger person's immune system is healthy and capable of eliminating damaged cells. But with age, senescent cells are no longer eliminated as effectively. They accumulate, cause inflammation and release enzymes that can damage tissue.
Fisetine, a senotherapeutic? Fisetin, by reducing the level of damaged cells in the body, leads to an increase in the lifespan of mice. Admittedly, there are still many steps to be taken before obtaining an effective therapeutic compound without toxic effects in humans, but this first demonstration already makes it possible to identify the beneficial effects of the candidate on specific subsets of these damaged cells. in a given fabric.
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